PATIENTS WITH UNCONTROLLED HYPERTENSION ARE AT RISK OF MAJOR CV EVENTS AND STROKE

*^ Based on an analysis of data from the 2009-2014 US National Health and Nutrition Examination Survey (NHANES). Analysis was restricted to participants aged ≥20 years who self-reported taking antihypertensive medication, had ≥1 class of antihypertensive medication identified during a pill bottle review conducted as part of the NHANES examination, and had ≥3 BP measurements obtained during their study exam (N=4158). The primary purpose of the study was to compare the prevalence and characteristics of adults with aTRH using the definitions in the 2018 versus the 2008 AHA Scientific Statement. Patients who were uncontrolled (defined as BP ≥130/80 mm Hg) with 2 classes of medication: 49.6% (95% CI: 45.2%–54.1%); 3 classes of medication: 57.0% (95% CI: 51.5%–62.4%); ≥4 classes of medication: 52.0% (95% CI: 45.6%–58.2%). The data used are based on the definition of uncontrolled HTN from the 2018 AHA Scientific Statement.^[1b]

^†^ Systematic review and meta-analysis of 123 randomized trials (published between 1966 and 2015) that evaluated the effects of BP lowering on CV disease and mortality across various baseline BP levels and comorbidities in 613,815 participants. Data were also extracted for major CV disease events (defined as fatal and nonfatal MI, sudden cardiac death, revascularization, fatal and nonfatal stroke, and fatal and nonfatal HF) and stroke (fatal and nonfatal, excluding TIA). The relative risks for events were as follows: major CV events: 20% (RR=0.80; 95% CI: 0.77–0.83); stroke: 27% (RR=0.73; 95% CI: 0.68–0.77).^[2b]